Topic outline
Lectures
Link for students 44-54 group
Saturday 11.40- 13.20
https://voovmeeting.com/dm/3faSyN5oUtwQ
#VooVMeeting: 395 0747 6406
Meeting Password: 5874LECTURE 1.
Introduction. A subject and tasks of biochemistry. Physical and chemical bases of biochemical processes. Structure of proteins. Structural organization and properties of proteins Interaction of proteins with ligands as a basis of functioning of proteins. The active center. Interrelation of proteins structure and function.Supplement
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LECTURE 2.
Enzymes. A biological role. The mechanism and features catalytic efficiency of enzymes. Cofactors and соenzymes.Supplement
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LECTURE 3.
Kinetics of enzymatic catalysis. Principles of determination enzymatic activity. Medical enzymology (enzymes in biotechnology and medicine).---------------------
LECTURE 4.
Biological oxidation. Mitochondrial electron transport chain. ATP-syntase. Regulation of oxidative phosphorylation. Disorders of mitochondrial oxidative phosphorylation.- ---------------------
LECTURE 5.
Carbohydrates: structure, biological role, classification. Digestion and absorption of food carbohydrates. Synthesis and catabolism of glycogen. Regulation of glucose storage and mobilization.- ---------------------
- LECTURE 6.
Glycolysis. Gluconeogenesis. Fermentation. Pentose phosphate pathway. Disorders of carbohydrate metabolism. - ---------------------
- LECTURE 7.
Lipids: structure, biorole, classification. Digestion of lipids and absorption of products of digestion in the gastrointestinal tract. Transport of lipids, lipoproteins. Storage and mobilization of fats in adipose tissue. Regulation. - ---------------------
- LECTURE 8.
Beta-oxidation of fatty acids. Oxidative degradation of glycerol. Biosynthesis of fatty acids. Regulation. Synthesis of triacylglycerols and phospholipids. - ---------------------
- LECTURE 9.
Synthesis and utilization of ketone bodies in organism. Metabolic acidosis. Biorole of cholesterol. Synthesis of cholesterol. Bile acids. Eicosanoids. Disturbances of lipids metabolism in organism. LECTURE 10:
Common pathway of amino acids. Deamination. Kinds of direct deamination. Oxidases of amino acids and glutamate dehydrogenase. Synthesis and degradation of glutamine. Transamination of amino acids Utilization of ammonia in urea cycle and removing of urea.
LECTURE 11:
Decarboxylation of amino acids. Biorole of biogenic amines. Polyamines. Degradation of biogenic amines. Metabolism of phenylalanine and tyrosine. Hereditary defects of phenylalanine catabolism (alcaptonuria and phenylketoneuria).
Proteins and Enzymes
Module 1 (5 Classes)
- Unit 1. Introduction to biochemistry. Physico-chemical properties of proteins. Levels of organization of proteins
- Manuals
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- Unit 2. Structure, properties and functions of proteins. The protein – ligand interaction. Quantitative assay of proteins in solution.
TEST IN WRITTEN FORM:
1)Name structural formulae of 20 amino acids
2) Write the formula of the peptide- Manuals
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- Unit 3. Enzymes. Biological role. Mechanism and features catalytic efficiency of enzymes. Cofactors and coenzymes.
- Test in written form:
The structural formulae of : NAD+, NADP, FAD, TPP, PLP, Biotin, tetrahydrofolic acid, CoASH. - Manuals
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- Unit 4. Kinetics of enzyme-catalyzed reactions. Principles of assay activity of enzymes.Medical enzymology (enzymopathology, enzymodiagnostics and enzymotherapy).
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- Unit 5. Regulation of enzyme activity as molecular basis of regulation of metabolism by external signals. Inhibition of enzyme activity.
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Bioenergetics
Module 2 (5 Classes)- Unit 6. Energy metabolism and ATP formation. Mitochondrial electron transport chain.
Read!!! Main Textbook : Satyanarayana from page 221 (Chapter 11).
- Supplement
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- Unit 7. Common catabolic pathway. Tricarboxylic acid cycle.
Read!!! Main Textbook : Satyanarayana Chapter 12 and Chapter 13.
- Supplement
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- Unit 8. Carbohydrate metabolism. Digestion of dietary carbohydrates. Glycogen metabolism. Regulation of glycogen metabolism.
Read!!! Main Textbook : Satyanarayana Chapter 2 and Chapter 13.
- Test in written form:
- Supplement
- Marks' Basic Medical Biochemistry
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- Unit 9. Catabolism of glucose.
- Supplement
Marks' Basic Medical Biochemistry
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- Unit 10. Gluconeogenesis. Regulation of glycolysis and gluconeogenesis. Pentose phosphate pathway.
LECTURES (3)
- Supplement
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Lipids. Biological membranes
Module 3 (3 Classes)- Unit 11. Digestion and Absorbption of Lipids. Lipiproteins.
Test in written form!!!
- Supplement
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- Unit 12. Lipid metabolism I.
- Supplement
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- Unit 13. Lipid metabolism II.
- Supplement
By Peter Forster - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=45808291
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