Course: Biochemistry (GenMed) Part1

Topic outline

Welcome to The Biochemistry Chair
Lectures
- Link for Lectures
  Time
  Link
- LECTURE 1.
  Introduction. A subject and tasks of biochemistry. Physical and chemical bases of biochemical processes. Structure of proteins. Structural organization and properties of proteins Interaction of proteins with ligands as a basis of functioning of proteins. The active center. Interrelation of proteins structure and function.
- Introduction File
- Lecture "Proteins". Part1. File
- Lecture "Proteins". Part 2. File
- Supplement
- What is Protein (PDB) File
- Test Lecture 1 Quiz
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- LECTURE 2.
  Enzymes. A biological role. The mechanism and features catalytic efficiency of enzymes. Cofactors and соenzymes.
- Lecture2 Enzyme definition, Terminology, Action mechanism Folder
- Supplement
- Enzimes (PDB) File
- Test Lecture 2 Quiz
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- LECTURE 3.
  Kinetics of enzymatic catalysis. Principles of determination enzymatic activity. Medical enzymology (enzymes in biotechnology and medicine).
- Lecture3 Enzyme regulation Folder
- Test Lecture 3 Quiz
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- LECTURE 4.
  Biological oxidation. Mitochondrial electron transport chain. ATP-syntase. Regulation of oxidative phosphorylation. Disorders of mitochondrial oxidative phosphorylation.
- LECTURE 4. Biological oxidation. File
- Test for Lecture "Biological Oxidation" Quiz
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- LECTURE 5.
  Carbohydrates: structure, biological role, classification. Digestion and absorption of food carbohydrates. Synthesis and catabolism of glycogen. Regulation of glucose storage and mobilization.
- Lecture 5. "Chemistry of carbohydrates" File
- Test for Lecture "Chemistry of carbohydrates" Quiz
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- LECTURE 6.
  Glycolysis. Gluconeogenesis. Fermentation. Pentose phosphate pathway. Disorders of carbohydrate metabolism.
- Lecture 6. "Metabolism of carbohydrates" File
- Test for Lecture "Metabolism of carbohydrates" Quiz
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- LECTURE 7.
  Lipids: structure, biorole, classification. Digestion of lipids and absorption of products of digestion in the gastrointestinal tract. Transport of lipids, lipoproteins. Storage and mobilization of fats in adipose tissue. Regulation.
- Lectures 7-9 "Lipids" File
- Test for Lecture 7 "Lipids" Quiz
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- LECTURE 8.
  Beta-oxidation of fatty acids. Oxidative degradation of glycerol. Biosynthesis of fatty acids. Regulation. Synthesis of triacylglycerols and phospholipids.
- Test for Lecture 8 Quiz
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- LECTURE 9.
  Synthesis and utilization of ketone bodies in organism. Metabolic acidosis. Biorole of cholesterol. Synthesis of cholesterol. Bile acids. Eicosanoids. Disturbances of lipids metabolism in organism.
- Test for Lecture 9. Quiz
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Proteins and Enzymes
Module 1 (5 Classes)
- Unit 1. Introduction to biochemistry. Physico-chemical properties of proteins. Levels of organization of proteins. .
- Main topics Page
- Cards for Unit 1 (P1) Quiz
- Manuals
- 1. STRUCTURE OF AMINO ACIDS File
- 2. LABORATORY MANUAL File
- What is a Protein? Learn about the 3D shape and function of macromolecules URL
- Homework Page
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- Unit 2. Structure, properties and functions of proteins. The protein–ligand interaction. Quantitative assay of proteins in solution .
- MAIN TOPICS. Page
  TEST IN WRITTEN FORM:
  1)Name structural formulae of 20 amino acids
  2) Write the formula of the peptide
- U2 (P1)_Aminoacids and Peptides (Written) Quiz
- Cards for Unit 2 (P1) Quiz
- E.Test for Units 1-2 Quiz
- Manuals
- 1. PROTEIN STRUCTURE File
- 2. LABORATORY MANUAL File
- CLASSIFICATION OF PROTEINS File
- Homework Page
- Table (homework) File
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- MAIN TOPICS Page
- Unit 3. Enzymes. Biological role. Mechanism and features catalytic efficiency of enzymes. Cofactors and coenzymes .
- MAIN TOPICS Page
- Test in written form:
  The structural formulae of : NAD+, NADP, FAD, TPP, PLP, Biotin, tetrahydrofolic acid, CoASH.
- U3.Test in written form Quiz
- Cards for Unit 3 (P1) Quiz
- Manuals
- PROPERTIES OF ENZYMES File
- Homework Page
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- Unit 4. Kinetics of enzyme-catalyzed reactions. Principles of assay activity of enzymes.Medical enzymology (enzymopathology, enzymodiagnostics and enzymotherapy).
- MAIN TOPICS Page
- Readings: Main TextBook (Satyanarayana)-
  Q1: pages 88-91
- Cards for Unit 4 (P1) Quiz
- ETest for Units 3 & 4 Quiz
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- Unit 5. Regulation of enzyme activity as molecular basis of regulation of metabolism by external signals. Inhibition of enzyme activity.
- MAIN TOPICS Page
- Cards for Unit 5 (P1) Quiz
- E.Test_Unit 5 Quiz
- M1_ ETest "Proteins and Enzymes" Quiz
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Bioenergetics
Module 2 (6 Classes)
- Unit 6. Bioenergetics of the cell. Mitochondrial electron transport chain.
- Read!!! Main Textbook : Satyanarayana from page 221 (Chapter 11).
- MAIN TOPICS Page
- Cards for Unit 6. Quiz
- ETest for Unit 6 Quiz
- Supplement
- ETC (Harvard) URL
- Q-circle URL
- ATP-syntase URL
- ATP syntase 2 URL
- Song Explanation URL
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- Unit 7. Common catabolic pathway. Tricarboxylic acid cycle.
- Read!!! Main Textbook : Satyanarayana Chapter 12 and Chapter 13.
- MAIN TOPICS Page
- Cards for Unit 7. Quiz
- ETest for Unit 7 Quiz
- Supplement
- PDH complex File
- Common Pathway URL
- Song Explanation URL
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- Unit 8. Carbohydrate metabolism. Digestion of dietary carbohydrates. Glycogen metabolism. Regulation of glycogen metabolism.
- Read!!! Main Textbook : Satyanarayana Chapter 2 and Chapter 13.
- You should know: Page
  Test in written form:
- LABORATORY MANUAL (Unit 8) Page
- MAIN TOPICS Page
- Cards for Unit 8. Quiz
- U8. Written test "Carbohydrate structure" Quiz
- Supplement
- Readings: for Unit 8 Page
  Marks' Basic Medical Biochemistry
- Carbohydrate structure&function URL
- O-glycosylation URL
- N-glycosilation URL
- Glucose Transporters (GLUTs and SGLTs) URL
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- Unit 9. Catabolism of glucose.
- MAIN TOPICS Page
- Read!!! Main Textbook ( Satyanarayana): pages 244-251 (Fig.13.2); pages 234-235 (Shuttles -Fig.11.12 and 11.13)
- Cards for Unit 9. Quiz
- ETest for Units 8 & 9 Quiz
- Supplement
- Readings: for Unit 9 Page
  Marks' Basic Medical Biochemistry
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- Unit 10. Gluconeogenesis. Regulation of glycolysis and gluconeogenesis. Pentose phosphate pathway.
- MAIN TOPICS Page
- Cards for Unit 10. Quiz
- U10. ETest_U10 Quiz
- Supplement
- The pentose phosphate pathway URL
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- Unit 11. Colloquium: Bioenergetics. Carbohydrates.
- Read Main Textbook : Satyananarayana from page 221
- THEORETICAL TOPICS FOR REVISION Page
- PreConcluding E.Test Quiz
- Cards for Unit 11 (P1-Colloquium) Quiz
Lipids.
Module 3 (5 Classes)
- Unit 12. Digestion and Absorbption of Lipids. Lipiproteins.
- MAIN TOPICS Page
  Test in written form!!!
- U12. Test in written form: Quiz
- Cards for Unit 12 Quiz
- Supplement
- Bile acids File
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- Unit 13. Lipid metabolism I.
- MAIN TOPICS Page
- Cards for Unit 13 Quiz
- ETest for Units 12 & 13 Quiz
- Supplement
- Lipolysis and lipases in white adipose tissue 2015 File
- FAT SIGNALS - Lipases and Lipolysis 2012 File
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- Unit 14. Lipid metabolism II.
- MAIN TOPICS Page
- Cards for Unit 14 Quiz
- ETest for Unit 14 Quiz
- Supplement
- Prostaglandin synthesis animation URL
- Cholesterol Logistic URL
- Cholesterol Logistic File
  By Peter Forster - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=45808291
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- Unit 15. Colloquium: Lipids.
- THEORETICAL TOPICS FOR REVISION Page
- U15. Cards for Colloquium Quiz
- U15_Pre-conclusion ETest Quiz
- Is This The Lecture ? URL
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Module 4. ()
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Topic outline

Welcome to The Biochemistry Chair

Lectures

Proteins and Enzymes

Bioenergetics

Lipids.

Test in written form!!!

Module 4. ()