Biochemistry (GenMed) Part1

Topic outline

• 

  Welcome to The Biochemistry Chair

  • Объявления Forum
  • Preface File
  • REGULATIONS FOR A CHEMICAL LAB File
  • List of recomended literature Page
  • Main Text Book File
  • PRACTICAL AND LABORATORY STUDIES ON BIOCHEMISTRY File
  • Lecture Shedule File
  • PLAN OF PRACTICAL LESSONS File
• 

  Lectures

  • Link for Lectures
    Time
    Link

  • LECTURE 1.
    Introduction. A subject and tasks of biochemistry. Physical and chemical bases of biochemical processes. Structure of proteins. Structural organization and properties of proteins Interaction of proteins with ligands as a basis of functioning of proteins. The active center. Interrelation of proteins structure and function.

  • Introduction File
  • Lecture "Proteins". Part1. File
  • Lecture "Proteins". Part 2. File
  • Supplement

  • What is Protein (PDB) File
  • Test Lecture 1 Quiz
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  • LECTURE 2.
    Enzymes. A biological role. The mechanism and features catalytic efficiency of enzymes. Cofactors and соenzymes.

  • Lecture2 Enzyme definition, Terminology, Action mechanism Folder
  • Supplement

  • Enzimes (PDB) File
  • Test Lecture 2 Quiz
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  • LECTURE 3.
    Kinetics of enzymatic catalysis. Principles of determination enzymatic activity. Medical enzymology (enzymes in biotechnology and medicine).

  • Lecture3 Enzyme regulation Folder
  • Test Lecture 3 Quiz
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  • LECTURE 4.
    Biological oxidation. Mitochondrial electron transport chain. ATP-syntase. Regulation of oxidative phosphorylation. Disorders of mitochondrial oxidative phosphorylation.

  • LECTURE 4. Biological oxidation. File
  • Test for Lecture "Biological Oxidation" Quiz
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  • LECTURE 5.
    Carbohydrates: structure, biological role, classification. Digestion and absorption of food carbohydrates. Synthesis and catabolism of glycogen. Regulation of glucose storage and mobilization.

  • Lecture 5. "Chemistry of carbohydrates" File
  • Test for Lecture "Chemistry of carbohydrates" Quiz
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  • LECTURE 6.
    Glycolysis. Gluconeogenesis. Fermentation. Pentose phosphate pathway. Disorders of carbohydrate metabolism.
  • Lecture 6. "Metabolism of carbohydrates" File
  • Test for Lecture "Metabolism of carbohydrates" Quiz
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  • LECTURE 7.
    Lipids: structure, biorole, classification. Digestion of lipids and absorption of products of digestion in the gastrointestinal tract. Transport of lipids, lipoproteins. Storage and mobilization of fats in adipose tissue. Regulation.
  • Lectures 7-9 "Lipids" File
  • Test for Lecture 7 "Lipids" Quiz
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  • LECTURE 8.
    Beta-oxidation of fatty acids. Oxidative degradation of glycerol. Biosynthesis of fatty acids. Regulation. Synthesis of triacylglycerols and phospholipids.
  • Test for Lecture 8 Quiz
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  • LECTURE 9.
    Synthesis and utilization of ketone bodies in organism. Metabolic acidosis. Biorole of cholesterol. Synthesis of cholesterol. Bile acids. Eicosanoids. Disturbances of lipids metabolism in organism.
  • Test for Lecture 9. Quiz
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• 

  Proteins and Enzymes

  Module 1 (5 Classes)

  • Unit 1.  Introduction to biochemistry. Physico-chemical properties of proteins. Levels of organization of proteins. .
  • Main topics Page
  • Cards for Unit 1 (P1) Quiz
  • Manuals
  • 1. STRUCTURE OF AMINO ACIDS File
  • 2. LABORATORY MANUAL File
  • What is a Protein? Learn about the 3D shape and function of macromolecules URL
  • Homework Page
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  • Unit 2.  Structure, properties and functions of proteins. The protein–ligand interaction. Quantitative assay of proteins in solution .
  • MAIN TOPICS. Page

    TEST IN WRITTEN FORM:
    1)Name structural formulae of 20 amino acids
    2) Write the formula of the peptide

  • U2 (P1)_Aminoacids and Peptides (Written) Quiz
  • Cards for Unit 2 (P1) Quiz
  • E.Test for Units 1-2 Quiz
  • Manuals
  • 1. PROTEIN STRUCTURE File
  • 2. LABORATORY MANUAL File
  • CLASSIFICATION OF PROTEINS File
  • Homework Page
  • Table (homework) File
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  • MAIN TOPICS Page
  • Unit 3.  Enzymes. Biological role. Mechanism and features catalytic efficiency of enzymes. Cofactors and coenzymes .
  • MAIN TOPICS Page
  • Test in written form:
    The structural formulae of : NAD+, NADP, FAD, TPP, PLP, Biotin, tetrahydrofolic acid, CoASH.
  • U3.Test in written form Quiz
  • Cards for Unit 3 (P1) Quiz
  • Manuals
  • PROPERTIES OF ENZYMES File
  • Homework Page
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  • Unit 4.  Kinetics of enzyme-catalyzed reactions. Principles of assay activity of enzymes.Medical enzymology (enzymopathology, enzymodiagnostics and enzymotherapy).
  • MAIN TOPICS Page
  • Readings: Main TextBook (Satyanarayana)-
    Q1: pages 88-91
  • Cards for Unit 4 (P1) Quiz
  • ETest for Units 3 & 4 Quiz
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  • Unit 5.  Regulation of enzyme activity as molecular basis of regulation of metabolism by external signals. Inhibition of enzyme activity.
  • MAIN TOPICS Page
  • Cards for Unit 5 (P1) Quiz
  • E.Test_Unit 5 Quiz
  • M1_ ETest "Proteins and Enzymes" Quiz
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• 

  Bioenergetics

  Module 2 (6 Classes)

  • Unit 6.  Bioenergetics of the cell. Mitochondrial electron transport chain.
  • Read!!! Main Textbook : Satyanarayana from page 221 (Chapter 11).
    

  • MAIN TOPICS Page
  • Cards for Unit 6. Quiz
  • ETest for Unit 6 Quiz
  • Supplement
  • ETC (Harvard) URL
  • Q-circle URL
  • ATP-syntase URL
  • ATP syntase 2 URL
  • Song Explanation URL
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  • Unit 7.  Common catabolic pathway. Tricarboxylic acid cycle.
  • Read!!! Main Textbook : Satyanarayana Chapter 12 and Chapter 13.
    

  • MAIN TOPICS Page
  • Cards for Unit 7. Quiz
  • ETest for Unit 7 Quiz
  • Supplement
  • PDH complex File
  • Common Pathway URL
  • Song Explanation URL
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  • Unit 8.  Carbohydrate metabolism. Digestion of dietary carbohydrates. Glycogen metabolism. Regulation of glycogen metabolism.
  • Read!!! Main Textbook : Satyanarayana Chapter 2 and Chapter 13.
    

  • You should know: Page

    Test in written form:
  • LABORATORY MANUAL (Unit 8) Page
  • MAIN TOPICS Page
  • Cards for Unit 8. Quiz
  • U8. Written test "Carbohydrate structure" Quiz
  • Supplement
  • Readings: for Unit 8 Page

    Marks' Basic Medical Biochemistry
    
  • Carbohydrate structure&function URL
  • O-glycosylation URL
  • N-glycosilation URL
  • Glucose Transporters (GLUTs and SGLTs) URL
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  • Unit 9.  Catabolism of glucose.
  • MAIN TOPICS Page
  • Read!!! Main Textbook ( Satyanarayana): pages 244-251 (Fig.13.2); pages 234-235 (Shuttles -Fig.11.12 and 11.13)
    

  • Cards for Unit 9. Quiz
  • ETest for Units 8 & 9 Quiz
  • Supplement
  • Readings: for Unit 9 Page

    Marks' Basic Medical Biochemistry
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  • Unit 10.  Gluconeogenesis. Regulation of glycolysis and gluconeogenesis. Pentose phosphate pathway.
  • MAIN TOPICS Page
  • Cards for Unit 10. Quiz
  • U10. ETest_U10 Quiz
  • Supplement
  • The pentose phosphate pathway URL
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  • Unit 11. Colloquium:  Bioenergetics. Carbohydrates.
  • Read Main Textbook : Satyananarayana from page 221
    

  • THEORETICAL TOPICS FOR REVISION Page
  • PreConcluding E.Test Quiz
  • Cards for Unit 11 (P1-Colloquium) Quiz
• 

  Lipids.

  Module 3 (5 Classes)

  • Unit 12.  Digestion and Absorbption of Lipids. Lipiproteins.
  • MAIN TOPICS Page

    Test in written form!!!

  • U12. Test in written form: Quiz
  • Cards for Unit 12 Quiz
  • Supplement
  • Bile acids File
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  • Unit 13.  Lipid metabolism I.
  • MAIN TOPICS Page
  • Cards for Unit 13 Quiz
  • ETest for Units 12 & 13 Quiz
  • Supplement
  • Lipolysis and lipases in white adipose tissue 2015 File
  • FAT SIGNALS - Lipases and Lipolysis 2012 File
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  • Unit 14.  Lipid metabolism II.
  • MAIN TOPICS Page
  • Cards for Unit 14 Quiz
  • ETest for Unit 14 Quiz
  • Supplement
  • Prostaglandin synthesis animation URL
  • Cholesterol Logistic URL
  • Cholesterol Logistic File

    By Peter Forster - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=45808291
    

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  • Unit 15. Colloquium:  Lipids.
  • THEORETICAL TOPICS FOR REVISION Page
  • U15. Cards for Colloquium Quiz
  • U15_Pre-conclusion ETest Quiz
  • Is This The Lecture ? URL
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  • Unit 18. Hidden  Structure and functions of membranes. Role of membranes in signal transduction.
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  Module 4. ()

  Not available